Influenza A
The Need
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Sizable burden on US healthcare system (see Figure)
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Current influenza vaccine efficacy is variable, but typically only 40-65%
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Flu epidemics occur annually, affecting ~10% of the global population
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Flu pandemics occur unpredictably every 20-50 years, affecting >25% of populace and causing global societal disruption
The Disease
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A seasonal respiratory infection caused by Influenza A virus and Influenza B virus
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Influenza A comprises ~85% of annual infections
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Morbidity and mortality is greatest in those over 65 years old, and in immunocompromised hosts
The annual burden of influenza in the USA
Our Inhibitor
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Our inhibitor acts via a novel mechanism targeting the influenza A nucleoprotein
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It is active against influenza A strains resistant to current approved therapies
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It is also active against highly pathogenic avian influenza strains H5N1 and H7N9