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BK Polyomavirus

The Disease

  • BKV infection is ubiquitous, acquired in childhood, and typically asymptomatic

  • A chronic but clinically silent infection is established in the urinary tract

  • Following immune suppression, BKV can reactivate in the kidneys and bladder

  • In kidney transplant patients, such reactivation can cause serious renal damage and lead to loss of the transplanted kidney

The Need

  • Current standard of care is to reduce immune suppression, but this is only partially effective and endangers the transplant

  • No specific antivirals exist for the prevention or treatment

Our Inhibitor

  • Our inhibitor is a small molecule with activity against all four genotypes of BKV

  • Unlike a neutralizing antibody, our inhibitor acts on an intracellular target

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